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The InflammoThrombotic
Response (ITR) Theory - Originally Called The 1994
Fleming Unified Theory of Vasclar Disease.

In 1994 and again in 1995 I presented my theory on what truly causes heart disease - Inflammation & Blood Clotting - in addition to many other diseases including:

Coronary Artery Disease (Heart Disease),
Cerebral Vascular Disease (Strokes),
Diabetes Mellitus (Diabetes),
Many Musculoskeletal Diseases (Joint problems),
Infections (e.g. SARS-CoV-2/COVID),
and various other Immune and Autoimmune Disorders


1. Altering homeostasis - the balance in biochemical pathways that maintain health and life.

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2. Altering the flow of ions across cell membranes. Interfering with the electrical homeostais of life.

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3. Altering the chemicals responsible for maintaining the creation of life.

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4. Altering the biochemical pathways responsible for controlling the function of cells critical for life. Failure to maintain this control results in cancer and death.

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In 1999 The Fleming Unified Theory of Inflammation and Vascular Disease with its Inflammation and Blood Clotting Components caused by Multiple Factors was published in The Textbook of Angiology. John C. Chang Editor, Springer-Verlag New York, NY. 1999.

Chapter 64. Pathogenesis of Vascular Disease. pp. 787-798. doi:10.1007/978-1-4612-1190-7_64,

In this same Cardiology Textbook are other chapters
I authored for physicians including
"Heart Failure",
"Nuclear Imaging",
in addition to the use of "Phosphodiesterase Inhibitors"
for "Heart Failure".

The figure explaining The Inflammation and Vascular/Heart Disease Theory is reproduced below showing among other things the role that infections play in this InflammoThrombotic Response (ITR) occurring frequently today and known as COVID-19.

2. Phosphodiesterase Inhibitors for "Heart Failure".


Submitted 1989. Published 1993.

The 1994 Fleming Unified Theory of Vascular Disease (ITR).
This two page drawing of the pathways requires a computer to see.

Fleming InflammoThrombotic Response (ITR) Theory.jpg
Right half of ITR Theory.jpg

Between 1999 and 2003 We Published Reseach Papers Showing How Bacteria Can Make Heart Disease Worse. Something I called "Bacterially Aggravated Atherosclerosis" [BAA].

These research findings also revealed the ability to find activation of the thymus gland when cardiac imaging was initiated within minutes of isotope administration - someone previously thought not to occur after adolescence - along with the presence of elevated antibody titers showing infection, elevated white blood cell (neutrophil) counts showing bacterial infection, and alterations in homocysteine (Hcy) in some instances. Elevations in Hcy is one of the first markers of a failing or failed immune system. 

With appropriate treatment directed at the offending infection, neutrophil counts, Hcy levels and antibody titers normalized showing successful treatment. With this improvement the thymus gland decreased its increased level (T-cells) of activity and the BAA coronary artery disease (CAD) improved, showing improved blood flow to the heart.

This Research and its [Measured] findings was made possible by the development of Fleming Method (FMTVDM), which made it Possible to Not Only Accurately Measure Changes within the Coronary Arteries supplying blood to the heart (Heart Disease) But Also the ability to Measure if Treatment of the BAA was working.

In 2004 we published "Stop Inflammation Now! " to help guide people in the types of changes they should consider

These recommendations and The Inflammation and Vascular Disease Theory were featured on
ABC's 20/20.

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Seaside Villa

In 2005 The Director of the Centers for Disease Control and Prevention (CDC) asked me to present both my ITR Theory and Fleming Method (FMTVDM) for Diagnostic Measurement of both CAD and Breast Cancer and the Use of FMTVDM to Measure Treatment Response of CAD and Breast Cancer at the CDC Conference being held in Greece.

For Breast Cancer,
FMTVDM was given the Acronym BEST
(Breast Enhanced Scintigraphy Test).

The Two Poster Sessions Presented at the 2005 CDC Conference are shown below.

Inflammation & Heart Disease 2005 CDC Conference in Greece.jpg
CDC Recognizes FlemingMethod for Breast Cancer in 2005 (Greece).jpg
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